DHEA (Dehydroepiandrosterone) is a hormone produced by the adrenal glands and is a steroidal precursor of both androgens and estrogens. Concentrations of DHEA and its metabolite, DHEA Sulfate, peak at about age 20 and then progressively decrease with advancing age.

DHEA and its principle metabolite DHEA sulfate were once consider unimportant and were overlooked by many researchers as simply weak androgens. However, scientists have found that DHEA levels drop in such illnesses as lupus and rheumatoid arthritis. A few studies have demonstrated low levels of DHEA in obesity, cardiovascular disease, non-insulin dependent diabetes, chronic fatigue syndrome and some types of cancer. There is speculation that low levels of DHEA might be partially responsible for age-related degenerative diseases and replacement therapy may be of value. Studies have also shown that DHEA stimulates the immune system.Many physicians feel that DHEA-S levels in the blood should be maintained in the range of 150-200 mcg/dl in women and 200-400 mcg/dl in men. A blood level test to determine your current status is available from you physician.

Side effects seems to be rare when patients maintain the above levels in their blood , however, at higher levels there is potential for adverse reactions. In women DHEA can be converted to testosterone which can cause acne along with oily skin and unwanted hair growth. This problem is minimized by keeping the daily dose at 50mg or less. Also, there is conversion to estrogen which may be dangerous in women with a history of breast cancer. Because DHEA is metabolized in the liver patients with a history of liver disease should be monitored closely to avoid toxicity. Men with enlarged prostates should discuss the benefits versus risks with their physicians due to the conversion of DHEA to testosterone.Recently, DHEA has been marketed as a nutritional supplement. However, we feel that it is more prudent to be under a physicians supervision while taking this or any other hormone.